Evidence reveals that people with psychiatric disorders have more difficulties managing stressors and using adaptive coping strategies to face up stressful life conditions ( Phillips et al., 2009). Moreover, the confinement and lockdown might particularly affect them, resulting in relapses or worsening the illness course, since they may be more susceptible to stress ( Kozloff et al., 2020). Individuals with a pre-existing psychiatric disorder are a vulnerable population: they have a higher risk of infection and of suffering complications of COVID-19 than those without a mental disorder, due to the illness per se, cognitive deficits and comorbid conditions (obesity, diabetes, hypertension) ( Shinn and Viron, 2020)( Yao et al., 2020). Different factors which may influence this increase in anxiety, stress and depression include: duration of lockdown and social distancing, lack of psychological or physical coping strategies, facing great changes, financial issues, changes in sleep and dietary patterns, and disruption of daily routines, amongst others ( Salari et al., 2020). Several studies focusing on the current situation demonstrated that the pandemic and the lockdown increased anxiety and depression in the general population ( Fullana et al., 2020)( Petzold et al., 2020)( Salari et al., 2020)( Wang et al., 2020)( Xiong et al., 2020). However, most of the studies published during the current COVID-19 pandemic have focused on psychological distress in the general population and few have focused on individuals with a pre-existing psychiatric disorder. The COVID pandemic has been devastating not only due to its direct impact on people's lives, physical health, and socio-economic status, but also for its impact on mental health. The Spanish government implemented a state of emergency from mid-March to late June, implementing at first strict lockdown measures all over the country which were then eased in stages in each region depending on the evolution of the infections in that area. On 31 January 2020, Spain confirmed its first case of COVID-19. Specific applications where next-generation sequencing has demonstrated utility in oncology are provided.As a result of the Coronavirus Disease 2019 (COVID-19) pandemic, governments around the world have made efforts towards tackling the virus and limiting disease transmission, focused on social distancing and the shutdown of non-essential services. This primer will review DNA sequencing technology, the commercialization of next-generation sequencing, and clinical uses of next-generation sequencing. Next-generation sequencing may be used in the clinical setting to look for specific genetic alterations in patients with cancer, diagnose inherited conditions such as cystic fibrosis, and detect and profile microbial organisms. Next-generation sequencing technology grew out of advances in multiple fields to produce a sophisticated laboratory test with tremendous potential. Since next-generation sequencing is relatively new, graduate students, medical students, pathology residents, and other physicians may benefit from a primer to provide a foundation about basic next-generation sequencing methods and applications, as well as specific examples where it has had diagnostic and prognostic utility.

The technology has been introduced into clinical laboratory testing and produces test results for precision medicine. Next-generation sequencing refers to a high-throughput technology that determines the nucleic acid sequences and identifies variants in a sample.

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